Advanced Materials, 12 January, 2024, DOI：https://doi.org/10.1002/adma.202309669

Low-Temperature Adaptive Single-Atom Iron Nanozymes against Viruses in the Cold Chain

Tao Qin, Yulian Chen, Xinyu Miao, Mengjuan Shao, Nuo Xu, Chunxiao Mou, Zhenhai Chen, Yuncong Yin, Sujuan Chen, Yinyan Yin, Lizeng Gao, Daxin Peng, Xiufan Liu

Abstract

Outbreaks of viral infectious diseases, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV), pose a great threat to human health. Viral spread is accelerated worldwide by the development of cold chain logistics; Therefore, an effective antiviral approach is required. In this study, it is aimed to develop a distinct antiviral strategy using nanozymes with low-temperature adaptability, suitable for cold chain logistics. Phosphorus (P) atoms are added to the remote counter position of Fe-N-C center to prepare FeN₄P₂-single-atom nanozymes (SAzymes), exhibiting lipid oxidase (OXD)-like activity at cold chain temperatures (−20, and 4 °C). This feature enables FeN₄P₂-SAzymes to disrupt multiple enveloped viruses (human, swine, and avian coronaviruses, and H1-H11 subtypes of IAV) by catalyzing lipid peroxidation of the viral lipid envelope. Under the simulated conditions of cold chain logistics, FeN₄P₂-SAzymes are successfully applied as antiviral coatings on outer packaging and personal protective equipment; Therefore, FeN₄P₂-SAzymes with low-temperature adaptability and broad-spectrum antiviral properties may serve as key materials for developing specific antiviral approaches to interrupt viral transmission through the cold chain.

文章链接：https://onlinelibrary.wiley.com/doi/10.1002/adma.202309669